Geoffrey Radcliffe, the wealthy owner of a coal mining operation, is running out of time. In two hours, he is set to be executed for the murder of his brother, a murder he did not commit. His fiancée, Helen Manson, is frantic. Geoffrey's cousin, Richard Cobb, tells her that he has done everything he can. Geoffrey's only hope is his friend, Dr. Frank Griffin. Griffin's late brother once discovered a secret drug that makes a human being invisible. The only trouble is, it also turns its subject mad. But now Geoffrey, Helen and Dr. Griffin have no other choice. Griffin visits Geoffrey at the prison and administers the drug. Soon Geoffrey, made invisible, is able to escape. As the wily Inspector Sampson of Scotland Yard searches for the escaped convict, Griffin frantically searches for an antidote and Geoffrey frantically searches for the real killer. Time is short. Geoffrey is slowly but surely going insane.
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