Grand Guignol theater actress Yvonne Orlac (Frances Drake) is married to concert pianist Stephen (Colin Clive) and plans to take a break from acting to tour with him. However, Dr. Gogol (Peter Lorre), her biggest fan, won't let her go so easily. When Stephen's hands are destroyed in an accident, Dr. Gogol's obsession with Yvonne leads him to replace Stephen's hands with those of a knife-wielding murderer who was sentenced to death. Soon, Stephen's new hands develop a mind of their own.
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